HARCP Archives

Browse by article

Browse by volume

Heroin Addiction and Related Clinical Problems: 2020, 22, N1 (pages: 7 - 8)

Mood Stabilizing Effects of Methadone in Opioid Use Disorder Patient

Gohari J., and Riaz U.

Summary: Lower doses of mood stabilizers may be necessary in patients receiving Methadone, especially when considering the metabolic syndrome and prolongation of QT interval which both Methadone and some psychoactive medications can cause. Research has shown that Methadone is a µ-opioid receptor agonist, as well as a serotonin and noradrenaline uptake inhibitor and NMDA receptor antagonist. Moreover, Methadone has the most evidence of efficacy in comorbid BD and opioid use disorder. We present here a case of a pregnant individual with a history of substance use disorder, BD-II and ADHD.