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Heroin Addiction and Related Clinical Problems: 2006, 08, 4 (pages: 9 - 28)

In the Service of Patients: The Legacy of Dr. Dole

Joseph H., Woods J. S.

Summary: The underlying theme in Dr, Vincent P. Dole's work is the effect of metabolism on behavior. This led to ground breaking investigations at The Rockefeller University in electrophoresis, lipids, obesity, addiction, and the development of methadone maintenance in 1964 with his late wife, Dr. Marie E. Nyswander. Dr. Mary Jeanne Kreek, a research resident in his laboratory in 1964, is now continuing addiction research as a professor at Rockefeller. Dole developed methadone detoxification in the New York City jail system and office based methadone medical maintenance with Nyswander. His major concern was to resolve the stigma that methadone patients encounter.