HARCP

HEROIN ADDICTION AND
RELATED CLINICAL PROBLEMS

The official journal of
EUROPAD - European Opiate Addiction Treatment Association
WFTOD - World Federation for the Treatment of Opioid Dependence
Editor: Icro Maremmani, MD - Pisa, Italy, EU
Associate Editors:
Thomas Clausen, MD - Oslo, Norway
Pier Paolo Pani, MD - Cagliari, Italy, EU
Marta Torrens, MD - Barcelona, Spain, EU
Statistical Editor:
Mario Miccoli, PhD - Pisa, Italy, EU

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Heroin Addiction and Related Clinical Problems: 2002, 04, 2 (pages: 5 - 9)

Correlation between hepatitis C serostatus and methadone dose requirement in 1.163 methadone-maintained patients

Maxwell S., Shinderman M. S., Miner A., Bennet A.

Summary: Hepatitis C infection is epidemic in intravenous drug users worldwide. This has great impact on opiate-addicted patients. Prevention of infection must depend on treatment of opiate addiction. This report discusses findings from 1,163 methadone-maintained patients tested for hepatitis C infection. The prevalence of HCV seropositivity in IVDU patients was 68%. Seropositive patients required significantly higher doses of methadone (169 mg/d vs. 100 mg/d, p<.05). This difference in dose was independent of duration of addiction and time in treatment. It is suggested that Hepatitis C infection may be associated with metabolic changes that lead to increased methadone requirement.

 

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