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Heroin Addiction and Related Clinical Problems: 2001, 03, 1 (pages: 7 - 12)

The promise of opioid receptor antagonist drugs in the treatment of neuropsychiatric disorders

Deltito J., Maremmani I.

Summary: The endogenous opioid system, either directly or through its influence on other neurotransmitter systems, has far-reaching effects on normal as well as abnormal (maladaptive) behaviours, thoughts and mood states. Altering this system through the use of an opioid antagonist medication may not only be useful in treating recognized psychiatric illnesses, but may also prove to be valuable in elucidating psychophysiological abnormalities that could contribute to the foundation of these disorders.