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Heroin Addiction and Related Clinical Problems: 2024, 26, 62

Investigating the Association Between Heroin Dose, Genetics, and Personality Disorders

Kadir Uludag, Hang Su, Haifeng Jiang, Jiang Du, Na Zhong, and Min Zhao

Digital Object Identifier:
https://doi.org/10.62401/2531-4122-2024-62

Summary: Background Heroin dependence, also known as heroin use disorder, is a chronic and relapsing condition characterised by a compulsive and uncontrollable urge to seek and use heroin despite its harmful consequences. Using heroin poses substantial dangers, such as the potential for overdose and the transmission of infectious diseases. Moreover, a heroin overdose can result in fatalities. Methods In a cross-sectional investigation, we enrolled 263 female participants to analyse the association between specific genetic elements, socio-demographic parameters, and heroin dose. Goals of study Our research aimed to investigate the connection between heroin dose and particular genetic components, along with personality disorders. Results We found a significant relationship between heroin dose and certain genetic factors related to COMT and stress pathway genes. Furthermore, we identified a relationship between heroin dose and antisocial personality disorder (p<0.05). However, we did not find a relationship between heroin dose and other personality disorders such as schizoid, depressive, histrionic, narcissistic, and paranoid personality disorders (p>0.05). Conclusion In conclusion, heroin dose is associated with specific genetic components related to COMT, stress pathway genes, and antisocial personality disorder.

Keywords: heroin use; addiction; heroin dose; COMT; genetic factors; polymorphism; personality disorders; stress pathway gene